Use of PPIs to treat persistent throat symptoms
Tue, 01/12/2021 – 02:30
U.K. researchers evaluated the effect of proton pump inhibitors on persistent throat symptoms in adult patients. Among 346 study enrollees, 172 were randomly assigned to treatment with lansoprazole and 174 were allocated to the control group. The intervention period lasted for 16 weeks, at which time investigators assessed the primary endpoint of symptomatic response. Mean scores using the total reflux symptom index (RSI) declined to 17.4 from 22 for the lansoprazole patients and to 15.6 from 21.7 for the placebo recipients. Based on the change in RSI scores, lansoprazole was no better than placebo for the main outcome nor for the secondary endpoints—which included symptom response at 1 year, quality of life, and throat appearance.