Coordinating and delivering research in the pandemic: The UK approach

The acute phase of the COVID-19 pandemic tested the UK’s capacity and capability to rapidly deliver crucial clinical research at a time of immense pressure and stress on personnel and resources.

It triggered a system-wide response which took the UK’s collaborative culture to new levels. This multi-agency approach enabled unprecedented speed and efficiency in trial approvals, set-up and recruitment. By eliminating delays and duplication, and optimising all available resources throughout our NHS, the UK was able to answer questions of global importance about COVID-19, including treatment and management.

Having successfully demonstrated our ability to coordinate, expedite and accelerate research delivery there is now an opportunity to reflect on what the UK did well and what this means for the future.

 

This pharmaphorum webinar, held in association with the National Institute for Health Research (NIHR), will take place on Thursday 25th February 13:00 GMT / 14:00 CET and discuss the UK’s approach to delivering research during the COVID-19 pandemic. It will examine lessons learnt from implementing complex design trials on a national scale and question what the UK could have done differently.

Focus

The webinar will also cover:

  • How research was prioritised
  • Processes for streamlining approvals
  • Learnings on site selection and set-up
  • Strategies for successful and rapid recruitment

View the webinar* by clicking on the link in the window above or by clicking here.

Our Panel

Kirsty WydenbachDr Kirsty Wydenbach is an expert medical assessor and the deputy unit manager in the Clinical Trials Unit at MHRA, having joined in 2009. She has been involved in the UK regulation of clinical trials across all therapy areas and all phases of development, including ATMPs and numerous first-in-human studies. She has also been involved in European discussions aiming to establish an EU harmonised approach to clinical trials, particularly for Developmental Safety Update Reports (DSURs) and Reference Safety Information (RSI). She was also an EMA expert for the update of the First-in-Human guideline. Other recent work has included collaboration with external industry groups and regulators regarding adaptive and novel trial designs: she is leading on this aspect for the MHRA in order to implement that aspect of the Life Sciences Industrial Strategy and was a contributor to the EU CTFG Recommendation Paper on the Initiation and Conduct of Complex Clinical Trials. More recently Kirsty has overseen the clinical trial work for COVID-19 and provided regulatory expertise on vaccines both within MHRA but also as part of the government Vaccine Taskforce.

Sir Terence Stephenson, Nuffield Professor, Child Health, UCLSir Terence Stephenson is an eminent clinical academic and took up the position of chair at the Health Research Agency on 1 September 2019. He is Nuffield Professor of Child Health at the University College London Great Ormond Street Institute of Child Health and Honorary Consultant Paediatrician at UCL Hospitals NHS Foundation Trust & Great Ormond Street Hospital for Children NHS Foundation Trust. Sir Terence is also a former Dean of the University of Nottingham’s Medical School, President of the Royal College of Paediatrics and Child Health, Chair of the Academy of Medical Royal Colleges, and most recently of the General Medical Council.

Professor Nick Lemoine, Medical Director, NIHR Clinical Research NetworkProfessor Nick Lemoine is medical director of the National Institute for Health Research Clinical Research Network for England. Nick has recently been appointed chair of the COVID-19 urgent public health studies group for the UK. The group’s remit is to consider all clinical studies relating to COVID-19 and to fast-track those with the greatest promise. Nick also chairs the NIHR Invention for Innovation Challenge Panel. Nick is director of the Barts Cancer Institute, Queen Mary University of London, and director of research & development for Cancer at Barts Health NHS Trust, the largest NHS Trust in the country. Among other commitments, he is the chair of Trustees of the Medical Research Foundation (the MRC’s independent charity), and executive dean of the Academy of Medical Sciences, Zhengzhou University, People’s Republic of China. He was elected as a Fellow of the Academy of Medical Sciences in 2006, and as a Foreign Academician of the Chinese Academy of Engineers in 2017.

Dominic-TyerDominic Tyer, interim managing editor, pharmaphorum [moderator] Dominic Tyer is a trained journalist and editor with 19 years of pharmaceutical and healthcare publishing experience. He serves as interim managing editor at pharmaphorum media, which facilitates productive engagement for pharma, bringing healthcare together to drive medical innovation. He is also creative and editorial director at the company’s specialist healthcare content consultancy, pharmaphorum connect.

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Introducing the new NIHR National Patient Recruitment Centres

The five new NIHR National Patient Recruitment Centres (NPRCs) are set to shape the future of commercial clinical trials in the UK by offering new ways to conduct late-phase, large-scale research projects.

One of the Sector Deal 2 commitments within the Government’s Life Sciences Industrial Strategy, the NPRCs are the first NIHR-funded research infrastructure that is 100% dedicated to delivering commercial research.

The regional NPRCs have been distributed across the country to provide opportunities for patients in regions across England who may not previously have been able to take part in cutting edge clinical studies.

They have also been designed to improve the speed and consistency with which commercial research is delivered in the NHS and, by making it easier and quicker to deliver commercial research, the NPRCs will improve the UK’s competitiveness in the global market.

This pharmaphorum webinar, held in association with the National Institute for Health Research (NIHR), takes place on Thursday 12th November, 14:00 GMT / 16:00 CET and will introduce the new NIHR National Patient Recruitment Centres and look at how the NPRCs will take a patient-centric approach to pharmaceutical research.

The expert panel will also discuss how the NPRCs will help patients benefit from early access to innovation and assist industry with new approaches to research, including virtual, hybrid and decentralised trials.

Focus

The webinar will also cover:

  • What the NPRCs’ franchise model means for research delivery
  • How the centres will provide quicker and easier clinical studies
  • How they will engage non-hospitalised patients with common chronic conditions
  • How they can serve as a test bed for pharmaceutical innovation
  • How they could facilitate clinical engagement with late-phase research

View the webinar* by clicking on the link in the window above or by clicking here.

Our Panel

Helen Quinn, Director, Joint Office for Clinical ResearchHelen Quinn is the Director of the Joint Office for Clinical Research, a collaboration between the University of Exeter and the Royal Devon and Exeter NHS Foundation Trust. Helen has previously held senior positions within the National Institute for Health Research (NIHR) Clinical Research Networks including chief operating officer and lead for nursing for the NIHR Clinical Research Network in the South West Peninsula. She has also held two national roles including director of delivery and business change director overseeing the amalgamation of the topic and comprehensive research networks.

Professor Dinesh Saralaya, Director, NIHR PRC, Bradford

Dinesh Saralaya has been a consultant respiratory physician and honorary senior lecturer at Bradford Teaching Hospitals NHS Foundation Trust since 2014. He has served as Director of the National NIHR Patient Recruitment Centre, Bradford since June 2020 and is also a visiting professor at the Faculty of Life Sciences at the University of Bradford. He leads the severe asthma service at Bradford Teaching Hospitals NHS Foundation Trust and the Respiratory Clinical Trials unit at the Bradford Institute for Health Research (BIHR). Dinesh set up the severe asthma service in Bradford Teaching Hospitals NHS Foundation Trust in 2006 and has published several of his research projects on severe asthma since then.

Yan Yiannkou, Clinical Director, PRC, Newcastle

Yan Yiannkou is a consultant gastroenterologist and Clinical Director of the NIHR Patient Recruitment Centre (Newcastle). He has been a director of R&D and has also served as regional clinical lead for commercial research for the NIHR Local Clinical Research Network (NENC). His main interest is in improving access to clinical trials through community-based participation, consent for contact registries and a digital media platform. He has used innovative and collaborative strategies to develop and refine a multi-modality ‘recruitment engine’ and led one of the UK’s first ‘virtual’ interventional trials.

Melanie Davies, Professor of Diabetes Medicine, University of LeicesterMelanie J Davies is Professor of Diabetes Medicine at the University of Leicester and an honorary consultant diabetologist at the University Hospitals of Leicester NHS Trust. She is based in the Diabetes Research Centre, University of Leicester and is also the Co-Director of the Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust. She is a National Institute for Health Research senior investigator emeritus, director of the NIHR Leicester Biomedical Research Centre and director of the Leicester Patient Recruitment Centre.

Dr Gavin Galasko, Cardiologist, Blackpool Teaching Hospitals NHS Foundation TrustDr Gavin Galasko BM BCh MA DM (Oxon) FRCP is a consultant interventional cardiologist and the Director of Research, Development and Innovation at Blackpool Teaching Hospitals NHS Foundation Trust. In 2017 he became the director of research, development and innovation for his Trust and in 2020 the Cardiology Research Team at Blackpool Teaching Hospitals won the research team of the year in the North West Coast annual research awards. He is an honorary senior lecturer at Liverpool University; an honorary senior research fellow at the University of Salford, and an honorary clinical senior lecturer at the University of Buckingham.

Dominic Tyer, Creative and Editorial Director, pharmaphorumDominic Tyer, Interim Managing Editor, pharmaphorum [moderator] Dominic Tyer is a trained journalist and editor with 19 years of pharmaceutical and healthcare publishing experience. He serves as interim managing editor at pharmaphorum media, which facilitates productive engagement for pharma, bringing healthcare together to drive medical innovation. He is also creative and editorial director at the company’s specialist healthcare content consultancy, pharmaphorum connect.

The post Introducing the new NIHR National Patient Recruitment Centres appeared first on .