When (and how) to use population-adjusted indirect comparisons?

Clinical Trials, Econometrics, Epidemiology, Evidence synthesis, PAIC / December 16, 2020

Population-adjusted indirect comparisons (PAICs) include both matching-adjusted indirect comparisons (MAICs) and Simulated treatment comparisons (STCs). The key data requirement for these methods is that they have individual patient data (IPD) from at least one clinical trial. This means the methods are most useful for studied funded by the clinical trial sponsor or when IPD clinical …

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