depression

Limbix’ digital therapeutic cuts depression symptoms in young people

Limbix is moving ahead with plans to file for FDA approval of its SparkRx digital therapeutic (DTx) for adolescents with symptoms of depression after reporting positive results in a clinical trial. SparkRx uses a programme of cognitive behavioural therapy (CBT) that is designed to be used alongside treatment by a clinician, and to provide a …

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Electrical implant treats severe depression in US patient

Researchers in the US have successfully treated a patient with severe depression via the use of an implant wired into the brain that interacts with a neural circuit linked to the disorder. The team from University of California, San Francisco (UCSF) describe the implant as a “pacemaker” for the brain and – while it needs …

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Smartphones could be used to detect depression, Verily finds

A study published by Verily researchers showed that some smartphone metrics, such as sentiment in weekly voice diaries, matched up with the severity of users’ depression as determined by PHQ-9 scores. Even if these technologies could be used to track mental health, it’s not clear how they will fit into physician workflows or how comfortable …

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Anxiety, Worry or Fear? Disappointment, Grief or Depression?

By HANS DUVEFELT Especially in these strange and uncertain times, many people feel uneasy. Some of them come to us with concerns over their state of mind. In primary care, our job is in large part to perform triage. We strive to identify patients who need referral, medication or further evaluation. We also strive, or …

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How Much Lead Leaches Into Organic Chicken Bone Broth?

“Lead poisoning still occurs in the United States despite extensive prevention efforts and strict regulations.” Ayurvedic supplements specifically marketed to pregnant women, for example, exceeded safety levels by up to 4 million percent, making Ayurvedic medicine use and lead poisoning “a continued concern in the United States.” In fact, “heavy metals are added intentionally to …

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Major Depressive Disorder Market Quadrant Growth Soars Owing to Expected Launch of Key Therapies

Depression is a common and serious medical condition that affects the way people behave, act and think in a negative manner. Also known as Major Depressive Disorder (MDD) or clinical depression, it leads to a persistent feeling of sadness. It affects more than 300 million people of all ages globally and is the leading cause …

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Axsome faces delay for depression drug, hitting shares hard

The FDA was supposed to be delivering its verdict on Axsome Therapeutics’ depression therapy AXS-05 in less than a fortnight – but instead has delivered the company a letter outlining deficiencies in its marketing application. The problem for the company is that it doesn’t yet know what those deficiencies are, and that uncertainty weighed heavily …

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Psoriasis and Depression: The Lesser-Known Impact of the Disease

By Nolan Brown, Marketing Intern, Butler University VMS BioMarketing Psoriasis is a chronic inflammatory disease of the skin that affects both the personal and social lives of the people it strikes. Psoriasis Awareness Month is an important time to discuss one of the lesser-known impacts of the disease. “Many people are familiar with the physical …

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Happify rolls out digital therapeutic for anxiety, depression under temporary FDA guidance

Happify is making its app-based treatment available to patients thanks to a loosened FDA guidance last year that lets digital health companies targeting some behavioral health conditions release their product without clearance. The company is launching an investigational study to get data for a future FDA submission.

Happify launches Ensemble DTx for depression, anxiety in US

Happify Health has launched a prescription digital therapeutic (DTx) – called Ensemble – that can assist the treatment of people with both major depressive disorder and generalised anxiety disorder in the US market. The 10-week smartphone or PC based programme is the first and only prescription DTx for both indications, which according to the digital …

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Digital mental health specialist Woebot raises $90m

Investments in digital health firms are running high at the moment, and a $90 million round for four-year-old Woebot and its artificial intelligence-powered platform for people with mental health ties firmly into that trend. The California-based startup has now raised $114 million from investors, and says it will use the new cash injection to further …

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Is There a Link Between Low Testosterone and Depression?

Testosterone is an essential hormone and steroid that affects many physiological functions. It is naturally more prevalent as an androgynous hormone in men, and it is therefore much more essential for them to have adequate amounts of it. However, with age, levels of this primary hormone can take a dive, usually for the worse. Symptoms …

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Sage/Biogen’s zuranolone works in depression, but maybe not enough

Sage Therapeutics and Biogen’s antidepressant candidate zuranolone has hit its objectives in a phase 3 trial, but a falloff in efficacy over time has raised concerns about the commercial potential of the drug. The WATERFALL trial of zuranolone showed that a two-week course of the oral GABAA receptor modulator significantly reduced symptoms of depression compared …

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While Sage Therapeutics sees a window for depression drug, market is skeptical

A Sage Therapeutics depression drug that failed a pivotal study in 2019 has positive preliminary results from a new Phase 3 clinical trial, but the data also showed the therapy’s effects waned over time. Questions about zuranolone’s durability are relevant to Biogen, which committed $1.5 billion to Sage in large part due to the drug’s …

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Study finds “alarming” hike in antidepressant costs during COVID-19

Researchers in the UK have found that there was a four million rise in prescriptions for antidepressants in England during 2020, adding £139 million to NHS costs. The team from the University of Huddersfield said the findings highlight an “urgent need” for new mental health strategies to make sure antidepressants are being used appropriately, particularly …

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Screening for Depression: Then What?

By HANS DUVEFELT Primary Care is now mandated to screen for depression, among a growing host of other conditions. That makes intuitive sense to a lot of people. But the actual outcomes data for this are sketchy. “Don’t order a test if the results won’t change the outcome” was often drilled into my cohort of …

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Small Pharma stock market launch funds DMT-based depression drug trial

UK-based Small Pharma has launched on the Toronto’s TSX Venture Exchange, raising 63 million Canadian dollars (around £37m) to develop medicines based on dimethyltriptylene (DMT) to treat depression. Small Pharma is following the trend for development of psychedelic medicines, a field where research has been suppressed for years because of legal restrictions on use of …

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To help tackle healthcare worker burnout, start talking about it

Healthcare staff are working through immense loss, grief and uncertainty to provide care during the Covid-19 pandemic. As organizations think about how to support their staff, speakers at a MedCity INVEST panel said they must first talk about it openly and provide a safe space for workers to discuss their feelings.

Magic mushroom compound matches antidepressant in clinical trial

The active compound in magic mushrooms – psilocybin – seems to be at least as effective as a commercially-available antidepressant in a phase 2 trial, and may work more quickly.  Researchers at Imperial College London’s Centre for Psychedelic Research also say that psilocybin may have a stronger effect and was more likely to help patients …

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How Artificial Intelligence Is Making Senior Care More Human

Bent Philipson, Founder of Philosophy Care When it comes to skilled nursing facilities (SNFs) in particular and long-term care in general, a human-centered and empathetic approach is not only necessary, it’s obligatory. Putting the needs, constraints, and perspectives of patients first enhances the level of care we’re able to provide.  Perhaps ironically, it is the …

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Tribunal maintains Lexon’s £1.2m fine for breaking competition law

Pharmaceutical wholesaler Lexon (UK) has lost its appeal against a £1.2 million fine in a case that accused it of exchanging commercially sensitive information about prices for nortriptyline tablets.  Lexon had appealed against a ruling by the UK’s Competition and Markets Authority (CMA) that it had exchanged information with King Pharmaceuticals and Alissa Healthcare Research …

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Otsuka, Click trial digital depression therapy with Google

Otsuka and Click Therapeutics are working with Verily, the healthcare subsidiary of Google owners Alphabet, on a fully remote clinical trial testing a digital therapy as an add-on in adults with severe depression. Otsuka is on a mission to develop digital technology to treat mental illness and broke new ground by marketed Abilify Mycite (aripiprazole) …

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98point6 Launches New Virtual Behavioral Health Offering

What You Should Know: – 98point6 announces the launch of its new virtual behavioral health service – 98point6 Primary Care Plus Behavioral Health. – With primary care at the center, 98point6’s new single-stop virtual care solution helps ensure that every patient is fully supported in their mental health treatment journey. – Currently available to commercial …

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Evaluating COVID-19’s Behavioral Health Impact on the Economy

Irv Lichtenwald, President & CEO of Medsphere Systems Corporation We’re now in a new year and new presidential administration. At least three companies are producing effective COVID-19 vaccines, which are being administered to healthcare workers, teachers, and the elderly. By summer, hopefully a large majority of the population in most countries will be vaccinated. From …

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Cedars Sinai Launches COVID-19 Recovery Program

What You Should Know: – Patients in the Cedars-Sinai COVID-19 Recovery Program receive a comprehensive in-person evaluation with an expert in infectious diseases or pulmonary medicine who can refer them to a network of specialists. Cedars-Sinai, today announce the launch of the COVID-19 Recovery Program to meet the needs of a growing number of COVID-19 patients who …

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Hurdle Secures $5M for Digital Mental Health Platform for People of Color

What You Should Know: – Washington, D.C.-based Hurdle raises $5M in seed funding to accelerate its digital mental health platform for people of color. – Hurdle aims to provide an innovative teletherapy solution for employers and insurers; aims to remove barriers to mental health care for People of Color by rooting its services in evidence-based …

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NeuroFlow Secures $20M for Tech-Enabled Behavioral Health Integration Platform

What You Should Know: – NeuroFlow raises $20M to expand its technology-enabled behavioral health integration platform, led by Magellan Health. – NeuroFlow’s suite of HIPAA-compliant, cloud-based tools simplify remote patient monitoring, enable risk stratification, and facilitate collaborative care. With NeuroFlow, health care organizations can finally bridge the gap between mental and physical health in order …

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Why Hospitals Should Act Now to Create Clinical AI Departments

John Frownfelter, MD, FACP, Chief Medical Information Officer at Jvion A century ago, X-rays transformed medicine forever. For the first time, doctors could see inside the human body, without invasive surgeries. The technology was so revolutionary that in the last 100 years, radiology departments have become a staple of modern hospitals, routinely used across medical …

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Watch Out For Top Pipeline Therapies Making An Impact In The Bipolar Depression Market

Characterized by debilitating episodes of depression and mood elevation (mania or hypomania), Bipolar depression is an under-recognized and unappreciated phase of bipolar disorder. Since most patients exhibit depression, Bipolar depression gets misdiagnosed with other mental disorders easily. Thus, it is associated with a heavier burden of illness, morbidity, and cost. Even then, there is no …

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Novartis buys neurology biotech Cadent for up to $770m

Novartis is to buy neuroscience drugs firm Cadent Therapeutics in a deal worth up to $770 million. The big Swiss pharma already has a presence in neurology with its multiple sclerosis drug Gilenya (fingolimod) and the more recently approved Aimovig (erenumab). With the acquisition of Cambridge, Massachusetts-based Cadent, Novartis gains rights to a portfolio of …

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VC fund dedicated to psychedelic meds launches in UK

In the last few years, biopharma companies focusing on psychedelic medicines have been springing up like mushrooms – magic or otherwise – and venture capital money is starting to follow. Today sees the launch of the first investment fund in the UK devoted to psychedelic healthcare, with plans to invest in “revolutionary mind-altering medicines to …

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Digital Diabetes Market to Reach $1.5B by 2024, Research Finds

What You Should Know: – The digital diabetes market is on track to reach $1.5 billion dollars by 2024, according to a new report by Research2Guidance. – The confident growth of digital diabetes care will be driven by the growth of the global addressable market for digital diabetes services. Between 2019 and 2024, the number of diagnosed diabetics …

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Zoloft enters list of 10 most commonly prescribed drugs in Australia

Increase in women being diagnosed with depression partly behind rise in use An increase in women being diagnosed with depression is partly behind a significant rise in prescriptions of the antidepressant sertraline – sold under the brand name Zoloft – which is in the list of Australia’s most commonly prescribed drugs for the first time. …

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Biogen bulks up pipeline with Sage drugs in $3bn deal

With the prospects for its Alzheimer’s drug aducanumab still up in the air, Biogen has moved to shore up its late-stage pipeline with a $3 billion licensing deal with Sage that adds drugs for depression and neurological disorders. The licensing agreement gives Biogen rights to Sage’s zuranolone (SAGE-217) for psychiatric disorders including depression, and SAGE-324 …

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How Care Coordination Technology Addresses Social Isolation in Seniors

Jenifer Leaf Jaeger, MD, MPH, Senior Medical Director, HealthEC Senior isolation is a health risk that affects at least a quarter of seniors over 65. It has become recognized over the past decade as a risk factor for poor aging outcomes including cognitive decline, depression, anxiety, Alzheimer’s disease, obesity, hypertension, heart disease, impaired immune function, …

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VHA, Ontrak Launch 3-Year AI Study to Help Prevent Veteran Suicide

What You Should Know: – The Veterans Health Administration has selected Ontrak in collaboration with Harvard Medical School and Brown University to transform suicide prevention care for veterans. – Leveraging AI developed by a Harvard Medical School professor and the core analytics of the Ontrak platform, the three-year study will look at the effect of …

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Ontrak Acquires Science-Backed, Behavior Change Platform LifeDojo

What You Should Know: – Ontrak acquires LifeDojo Inc, a San Francisco, CA-based comprehensive, science-backed behavior change platform. – The acquisition broadens Ontrak’s addressable market and footprint to lower acuity populations enabling new interventions and remote patient monitoring. Ontrak, Inc., a leading AI-powered and telehealth-enabled, virtualized healthcare company, today announced that it has acquired LifeDojo …

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COVID-19 Pandemic Further Exposes Systemic Racism…

Michael A Greely, Co-Founder & General Partner at Flare Capital Partners This will be ugly and sad. Racism has cost this country $16 trillion over the last twenty years according to a recent Citigroup report. Much of this loss ($13 trillion) was attributed to discriminatory lending practices and the 6.1 million fewer jobs created as a …

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70% Taking Common Antidepressants Suffer Sexual Side Effects

What’s the latest on treating depression with the spice saffron? Years ago, I covered a head-to-head comparison of saffron versus Prozac for the treatment of depression in my video Saffron vs. Prozac, and saffron seemed to work just as well as the drug. In the years since, five other studies have found that saffron beat …

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Were We Mentally Ready for COVID-19? Why It’s Time to Take Behavioral Health Seriously

Dr. Jacob Lazarovic M.D., IMCS Group As you read this, over 200,000 American deaths have been attributed to the virus. The influx of cases continues, while state and local economies are experiencing hardship, children are shuttered in their homes learning remotely, grown children are moving back home and the “new normal” disrupts nearly all of …

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AWS, PHDA Collaborate to Develop Breast Cancer Screening and Depression Machine Learning Models

What You Should Know: – Amazon Web Services (AWS) and the Pittsburgh Health Data Alliance (PHDA) announce a collaboration to produce more accurate machine learning models for breast cancer screening and depression. – In work funded through the PHDA-AWS collaboration, a research team led by Shandong Wu, an associate professor at the University of Pittsburgh …

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Why Hasn’t A More Holistic Approach to Patient Care Become The Norm?

When food production technology made it possible, wheat flour processors started to eliminate the tough exterior (bran) and nutrient-rich core (germ) of the kernel to get at the large, starchy part (the endosperm) only. The bread produced from this process is white and fluffy, and it makes great PB&Js and takes forever to grow mold, …

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Anthem Expands Relationship with doc.ai to Power Digital Health Offerings

What You Should Know: – Anthem extends the use of doc.ai’s platform and portfolio of privacy-first technologies and artificial intelligence software services to drive the personalization of Anthem’s digital assets and create improved value for users. – doc.ai’s product offerings are deployed on its cloud-agnostic and zero-trust infrastructure that lets clients like Anthem launch products …

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Lyra Health Reaches $1.1B Valuation After $110M Series D to Meet Demand for Teletherapy

What You Should Know: – Mental health benefits provider Lyra Health raises $110M in Series D funding, bringing its valuation to $1.1 billion. – Lyra has grown significantly in 2020. So far this year, the company has added more than 800,000 new members to the population eligible to receive Lyra benefits, bringing its total member …

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Sonde Health Acquires NeuroLex Lab’s Voice-Based Survey Platform

What You Should Know: – Sonde Health acquires NeuroLex Laboratories, Inc. to forms one of the world’s preeminent biobanks focused on vocal biomarkers. – NeuroLex’s core product, SurveyLex, makes it easy to create and distribute voice surveys in less than a minute as URL links through web browsers. Sonde Health, a Boston-based digital vocal biomarker …

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Led by Mount Sinai, Trellus Health Nabs $5M for Precision Platform for Complex Chronic Conditions

What You Should Know: – Trellus Health secures $5M in seed funding and collaborates with Mount Sinai to deliver resilience-driven, connected care, integrating expert clinical and behavioral health for better outcomes. – The first disease Trellus will tackle is IBD, which is one of the costliest chronic conditions with a high mental health burden. Trellus …

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Digital depression therapy offers hope during COVID-19 pandemic

A new digital therapy is aiming to tackle depression during the COVID-19 pandemic, using a brain stimulation headset and therapy app that claims to have similar beneficial effects to drugs but with fewer side-effects. Flow is the first drug-free at-home treatment of its type to be approved in the EU and UK. While using the …

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Ginger Lands $50M to Expand On-Demand Mental Health Support Platform

What You Should Know: – Ginger announces $50 Million in Series D funding to expand access to its on-demand mental healthcare system led by Advance Venture Partners and Bessemer Venture Partners; joined by Cigna Ventures and existing investors. – Company has more than tripled revenue over the past year, now brings access to on-demand mental …

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Innovaccer, CareSignal Partner to Enable Deviceless Remote Patient Monitoring

What You Should Know: – Innovaccer has recently partnered with CareSignal to address healthcare’s urgent need amidst the COVID-19 pandemic: to create and maintain solid, clinically actionable relationships with patients in a new set of predominantly virtual care. – CareSignal offers evidence-based end-to-end support services for chronic medical conditions such as asthma, CHF, COPD, diabetes, …

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Lemonaid Health Raises $33M to Expand On-Demand Consumer Telehealth Platform

– Lemonaid Health, a direct to consumer telehealth company raises $33M in Series B funding to expand the company’s medical team and number of services being offered to patients. – To date, the company has treated more than a million patients online for a variety of medical conditions ranging from erectile dysfunction to sinus infections to …

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Virtual Behavioral Health Could Reduce Costs, Improve Patient Outcomes, Report Finds

What You Should Know: – A new Accenture report called “Breakthrough Behavioral Health Access: Think Virtual” finds that the use of virtual behavioral health could expand care for more than 53 million Americans facing these conditions. – Demand for behavioral health specialists significantly outweighs current availability; in addition to severe wait times of 25 days …

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Eating Seaweed Salad May Boost Immune Function

Eating seaweed salad may boost the efficacy of vaccinations and help treat cold sores, herpes, Epstein-Barr virus, and shingles. Billions of pounds of seaweed are harvested each year, the consumption of which “has been linked to a lower incidence of chronic diseases,” both physical and mental. For example, women who eat more seaweed during pregnancy …

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The Benefits of Slow Breathing

There are all manner of purported hiccup “cures,” which include everything from chewing on a lemon, inhaling pepper, or, our dog’s favorite, eating a spoonful of peanut butter. In my video How to Strengthen the Mind-Body Connection, I talk about the technique I’m excited to try the next time I get hiccups: “supra-supramaximal inspiration,” where …

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