AT132

Astellas Pauses Dosing of AT132 in ASPIRO Clinical Trial for the Treatment of X-linked Myotubular Myopathy

ASPIRO Clinical Trial, Astellas, AT132, Clinical Trials, Dosing / September 2, 2021

Shots: Astellas discontinue the dosing in the ASPIRO trial that evaluates AT132 in 24 participants (7 at the 1.3×1014 vg/kg dose and 17 at the 3.5×1014 vg/kg dose) with XLMTM. The participant has a history of intermittent cholestasis The discontinuation is due to serious AEs in a study that demonstrated abnormal LFTs in patients who …

Astellas Pauses Dosing of AT132 in ASPIRO Clinical Trial for the Treatment of X-linked Myotubular Myopathy Read More »

Astellas’ Audentes Therapeutics discloses third patient death in gene therapy trial

Astellas Pharma, AT132, audentes therapeutics, BioPharma, biopharma nl, Daily, gene therapy, Japan, SYN, Tokyo, Top Story, XLMTM / August 21, 2020

The clinical trial had already been placed on hold in connection with the two prior patient deaths, which were linked to the higher dose of 300 trillion viral vectors per kilogram, while no deaths have been reported among those receiving the lower dose of 100 trillion vectors.

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