How microglia contribute to Alzheimer’s disease

A new study shows how a type of cells called microglia contribute to the slowdown of neuron activity seen in Alzheimer’s disease. The study found that microglia that express the APOE4 gene, one of the strongest genetic risk factors for Alzheimer’s disease, cannot metabolize lipids normally, leading to a buildup of excess lipids that interferes with nearby neurons’ ability to communicate with each other.