Healthcare Pharma and Nutrition

GoHealth’s net loss increased six-fold to $37.2 million during the second quarter.

Bridge Policy Think Tank, a legal research foundation which undertakes legislative and policy research, has been asked to do a comparative study of drug pricing policies of the UK, US, Australia, Brazil, Sri Lanka Bangladesh, European Union, Thailand, China and South Africa, among other countries and regions.

2022 Meeting Materials, Obstetrics, Reproductive and Urologic Drugs Advisory Committee (formerly Bone, Reproductive and Urologic Drugs Advisory Committee)

Once again, the United States is messing up its approach to vaccines. Three months into its monkeypox outbreak, just 620,000 doses of the two-injection Jynneos shot—the nation’s current best immune defense against the virus—have been shipped to states, not nearly enough to immunize the 1.6 million to 1.7 million Americans that the CDC considers at …

America’s New Monkeypox Strategy Rests on a Single Study Read More »

2019 Meeting Materials, Bone, Reproductive and Urologic Drugs Advisory Committee (formerly Advisory Committee for Reproductive Health Drugs (ACRHD))

As displayed in the Federal Register notice on August 1, 2018, FDA is conducting a Complex Innovative Designs (CID) Pilot Meeting Program to support the goal of facilitating and advancing the use of complex adaptive, Bayesian, and other novel clinical trial designs, as highlighted in the sixth iteration of the Prescription Drug User Fee Act …

Complex Innovative Trial Design Meeting Program Read More »

The Medicare Advantage insurer will cover seniors in a total of four states, pending regulatory approval.

Removing moles and other growths on our skin isn’t a DIY project, and can be dangerous to try. There are no FDA-approved drugs for treating moles, seborrheic keratoses, or skin tags. But there are potentially dangerous products being sold claiming to help remove these lesions. Avoid these products.

Cryo-electron microscopy is a technique that’s been coming on for years and is continuining to take new territory in the world of structural biology. But there’s a related (and even more intense) imaging method that’s coming up behind it. The advances in cryo-EM (sensitivity, contrast, deconvolution of the data, etc.) are all directly applicable to …

Inside Living Cells Read More »

The insurtech’s net loss quadrupled to $251 million during the second quarter and the company needs capital to to get to break even, CEO Mike Mikan told investors.

A ransomware attack at a vendor exposed data on almost 2 million patients, according to a report submitted to the Health and Human Service’s breach portal.

The FDA authorized a new plan that could lead to a five-fold increase in available doses. European health officials may follow the agency’s lead. 

The not-for-profit health system, which operates six day care centers, told employees in July it would end the program later this year, citing financial pressures and staffing issues. 

Hospitals pushed back on the Patient Rights Advocate report, which found that just 16% of hospitals were fully compliant with the price transparency law.

Miruna Sasu is on a mission to use real world data to help wipe out cancer. She believes this audacious goal is within reach, and as president and CEO of COTA, she is inspiring her team to create a “path to care” for oncology patients.

A consultant’s view on how pharma companies should approach patient experience challenges when rolling out an autologous cell therapy.

Cerner allegedly discriminated against qualified Black and Asian applicants, according to the Labor Department.

Hiring bias, which Cerner denies, resulted in a notable shortfall of Black and Asian hires for certain positions between 2015 and 2019, federal regulators allege.

Shots:  Laurent spoke about the study design of its nanoparticle therapy to enhance the cancer-killing effect of radiation, which was presented at ASCO 2022 Laurent also highlighted how this nanoparticle therapy can be a potential radio enhancer in various tumor types and across lines of therapy The interview summarizes Nanobiotix’s vision to advance nanoparticles across …

PharmaShots Interview: Laurent Levy, CEO of Nanobiotix Shares Insights and Clinical Updates on its Nanoparticle Therapy Read More »

Shots: The 1st patient has been dosed in the P-I/II study in which the P-I dose escalation study evaluates the safety of GDA-201 in patients with FL, DLBCL/HGBL, MZL & MCL whereas the P-II expansion study evaluates the safety & efficacy of GDA-201 in patients (n=63) divided into two groups with either FL or DLBCL …

Gamida Cell Reports First Patient Dosing in P-I/II Study of GDA-201 for the Treatment of Follicular and Diffuse Large B Cell Lymphoma Read More »

Shots: Under the terms of the agreement, Just-Evotec will develop a commercial manufacturing process for Alpine’s ALPN-303 using its data-driven technology platform, J.DESIGN with the commercial development activities to be performed at its J.POD biomanufacturing facility The extension of the partnership was based on the 2020 collaboration under which Just-Evotech provided drug substance materials through …

Just-Evotec Biologics Expands its Partnership with Alpine Immune Sciences for the Commercial Process Development of ALPN-303 to Treat Systemic Lupus Erythematosus Read More »

Newly diagnosed patients will become the first to access systemic light chain amyloidosis treatment in the UK

Partnership will focus on the discovery of novel targets in Alzheimer’s disease

Shots: The P-II (CIBI112A201) study evaluating picankibart (50/100/200mg) vs PBO in a ratio (1:1:1:1:1) in 250 patients with mod. to sev. PsO The trial met its 1EPs i.e., 52.0% to 54.9% of patients achieved PASI 90 @16wks.; PASI 75 & 100 were significantly higher over PBO. At 28wks., long-term efficacy was observed with 61.2% to …

Innovent’s Picankibart (IBI112) Meet its Primary Endpoint in the P-II (CIBI112A201) Study for the Treatment of Plaque Psoriasis Read More »

All children aged between one and nine in Greater London are to be offered a polio booster jab in a campaign likely to be spearheaded by GP practices after traces of the disease were found in sewage.

Shots: The P-Ib (TROPION-Lung02) trial evaluating datopotamab deruxtecan (4 & 6mg/kg) + pembrolizumab (200mg) with/out Pt CT (carboplatin or cisplatin) in patients with advanced or metastatic NSCLC without actionable genomic alterations The results showed a promising clinical activity along with a tolerable safety profile. In an interim analysis, ORR in the overall population of 37% …

AstraZeneca and Daiichi Sankyo Present P-Ib (TROPION-Lung02) Trial Results of Datopotamab Deruxtecan (Dato-DXd) for Advanced NSCLC at WCLC 2022 Read More »

He will continue to serve in his current position until the identification, selection and transition to the new leadership takes place in the company, it added.

Shots: Cerevance to receive a $25M up front & is eligible to receive ~$1.1B in development & commercial milestones along with royalties on sales of approved products that emerge from the collaboration The collaboration will use Cerevance’s NETSseq technology platform to identify novel targets for AD. Additionally, Cerevance will out-license one discovery-stage program to Merck …

Merck Entered into a Multi-Year Strategic Research Collaboration with Cerevance to Discover Novel Targets Using NETSseq Technology for Alzheimer’s Disease Read More »

Shots: Cerevance to receive a $25M up front & is eligible to receive ~$1.1B in development & commercial milestones along with royalties on sales of approved products that emerge from the collaboration The collaboration will use Cerevance’s NETSseq technology platform to identify novel targets for AD. Additionally, Cerevance will out-license one discovery-stage program to Merck …

Merck Entered into a Multi-Year Strategic Research Collaboration with Cerevance to Discover Novel Targets Using NETSseq Technology for Alzheimer’s Disease Read More »

Shots: Mersana to receive $100M up front. If GSK exercises its option, Mersana will eligible to receive ~$1.36B in option exercise, development, regulatory & commercial milestones Mersana also holds options for US profit-sharing & co-promotion of XMT-2056 in the US. If it exercises its option, Mersana will receive tiered royalty in Ex-US markets. If not, …

GSK Entered into an Option Agreement with Mersana to Co-Development and Commercialize XMT-2056 for the Treatment of Cancer Read More »

Submissions are now open to give feedback about the Child Dental Benefits Schedule to improve the service.

[Federal Register Volume 87, (Wednesday, August 10, 2022 )] [Notice] [Pages 48694-48695] National Advisory Committee on Occupational Safety and Health (NACOSH): Notice of Meeting

Researchers have shown that an experimental nanoparticle-based drug therapy protects mice from sudden death due to the rupture of a major blood vessel in the abdomen, pointing the way toward a new strategy for treating deadly abdominal aortic aneurysms.

Researchers have identified a molecular pathway responsible for the spread of glioblastoma to surrounding tissue in the brain, as well as an existing drug that curbed tumor growth in animal models. The findings have led to a clinical trial that could offer new hope to patients with glioblastoma, the most common form of brain cancer …

Scientists identify pathway to curb spread of brain cancer Read More »

The Blue Cross Blue Shield Association faces additional legal challenges from providers and patients who opted out of the deal.

Regulators continue to adjust prior authorizaiton guidelines as they try to boost high-value procedures and limit administrative burden.

Horizon Blue Cross Blue Shield of New Jersey and Cigna recently announced they plan to heighten oversight of evaluation and management claims that include modifier 25. 

Horizon Blue Cross Blue Shield of New Jersey and Cigna recently announced they plan to heighten oversight of evaluation and management claims that include modifier 25. 

The Justice Department sued Idaho last week over the state’s strict abortion ban, saying it would force doctors to violate the Emergency Medical Treatment and Labor Act.

Dozens of hospital and health system CEOs have retired in the past six months, kicking succession plans into overdrive.

All but two of the seven largest insurers saw profits climb in the second quarter as hospital operators continued to struggle with weak volumes and higher labor costs amid record-high inflation.

Scientists have developed a new mathematical model that may help clinicians decide on the best combination of osteoporosis medications for patients and the order in which they should be taken.

A common method of administering drugs is orally, by swallowing a pill or capsule. But oral administration is the most complex way for the human body to absorb an active pharmaceutical ingredient, because the bioavailability of the drug in the gastrointestinal tract depends on the medication’s ingredients and the stomach’s dynamic physiological environment. Researchers have …

Body posture affects how oral drugs absorbed by stomach Read More »

A new techniques enable unprecedented versatility in the design of drug molecules.

In a proof-of-concept study, researchers have shown that microrobots can access the difficult to reach surfaces of the root canal with controlled precision, treating and disrupting biofilms and even retrieving samples for diagnostics, enabling a more personalized treatment plan.

Estimates suggest nearly 20% of adults over 65 will experience some form of mental health challenge, and nearly 5% will have a severe mental illness.

I was just talking here about targeted protein degradation, not for the first time, and in almost every case when you’re talking TPD you’re talking ubiquitination. Ubiquitin, as the name indicates, is indeed all over the place. It’s a small protein (76 amino acids), but it doesn’t quite qualify for being one of those “microprotein” …

The Ubiquitin Universe Read More »

Information on FDA-approved drugs released for sale on the market, such as dosage, side effects, and disposal methods

The cost of an attack on a healthcare system has risen about 10% to more than $10 million.

Physical security is a major concern for hospitals, as threats of violence put patients and providers at risk. A 2022 report from video surveillance company Pro-Vigil reveals that 28 percent of respondents experienced a general increase in physical security incidents in 2021, up from 20 percent in 2020. Additionally, about 27 percent anticipate such incidents …

Review: Gain Better Sight and Insight with the Verkada CD52 Dome Camera Read More »

The health system and the healthcare conglomerate plan to collaborate on nurse training, technology and Black cancer patients.

Morphogens are the secreted molecules that pattern embryonic tissues. These molecules are important not only for the embryo during development, but also for the adult during tissue repair. However, the way these morphogens are distributed to ensure patterning occurs is still not fully understood. Using a combination of experiments and mathematical modeling, researchers learned more …

Future medical applications in drug design Read More »

A historically overlooked rod-like projection present on nearly every cell type in the human body may finally be getting its scientific due: A new study has found that these appendages, called cilia, on neurons in the brain have a key role in ensuring a specific dopamine receptor’s signals are properly received.

The latest funds build on $16 billion invested by the Biden administration to bolster rural healthcare last year, according to the HHS.

The Oakland, California-based integrated health system attributed the setback in its quarterly results to market investments.

Finished Pharmaceuticals/Unapproved New Drug

Finished Pharmaceuticals/Unapproved New Drug

Finished Pharmaceuticals/Unapproved New Drug

With Andrew Hall at its helm, IMV has evolved an animal contraceptive into a unique drug delivery platform aimed at creating targeted cancer immunotherapies for humans.

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The dependability of digital technology has augmented through a variety of industries, including communication, transportation, manufacturing, medical, and pharmaceutical companies. Development in technologies has made it possible to merge medical science with digital platforms, allowing for the individualised delivery of services to a large population, making therapy more effective and convenient. Today, technology has become …

The Emergence of Artificial Intelligence in the Pharmaceutical Industry Read More »

In a call with investors, incoming chief executive Andrew Toy said the path to profitability is “a huge focus” for Clover, and pointed to shrinking its medical loss ratio and controlling operating expense growth as key strategies.

Chronic obstructive pulmonary disease phase 3 study shows statistically significant improvements in lung function

Patents show potential of innovative Arestat technology and the development of enhanced formulations